Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Epidermal Growth Factor-Like Domain Multiple 7 (EGFL7)
- Target
- EGFL7
- Molecular classification
- Secreted protein, Extracellular matrix protein, Growth factor-like protein
01
Overview
EGFL7 is a secreted protein primarily expressed by endothelial cells and plays a critical role in blood vessel development during both physiological and pathological angiogenesis. It modulates Notch signaling and influences key processes like angiogenesis, vasculogenesis, and neurogenesis. Aberrant expression is linked to tumor angiogenesis, growth, and metastasis across several cancers.
02
Mechanism of action
Modulates Notch signaling; promotes endothelial cell migration, proliferation, and sprouting; enhances EGF receptor-AKT signaling pathway
03
Biological functions
AngiogenesisVasculogenesisEndothelial cell migrationEndothelial cell proliferationVascular tubulogenesisNotch signaling modulationCell adhesionSproutingNeurogenesis
04
Disease associations
CancerTumor angiogenesisMetastasisVascular remodelingAtherosclerosis
05
Safety considerations
Potential for off-target effects due to modulation of angiogenesis in normal tissues.Complex role in different cancer types may require careful patient selection.
06
Biomarkers
Prognostic marker in colorectal cancerPrognostic marker in hepatocellular carcinomaPrognostic marker in gliomaPrognostic marker in gastric cancer
Beyond the preview
Go deeper on Epidermal Growth Factor-Like Domain Multiple 7 (EGFL7).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Epidermal Growth Factor-Like Domain Multiple 7 (EGFL7).