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Target intelligence / Profile preview
ERBB Family Receptor Tyrosine Kinases (ERBBs)
- Target
- ERBBs
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The ERBB family, also known as the epidermal growth factor receptor (EGFR) family, comprises four closely related receptor tyrosine kinases: EGFR/ERBB1/HER1, ERBB2/HER2/Neu, ERBB3/HER3, and ERBB4/HER4. These receptors are critical regulators of cell proliferation, survival, differentiation, and migration in both development and adult tissue maintenance. Dysregulation, often via overexpression or mutation, is implicated in various cancers. EGFR and HER2 are validated targets for anti-cancer therapies.
- Other names
- Epidermal Growth Factor Receptor (EGFR) FamilyHER Family
02
Mechanism of action
Inhibition of tyrosine kinase activity; blockade of ligand binding/dimerization
03
Biological functions
Cell proliferationCell survivalCell differentiationCell migrationSignal transductionOrgan developmentTissue homeostasis
04
Disease associations
Cancer (Breast, Lung, Ovarian, etc.)
05
Safety considerations
Resistance to therapyOff-target effectsDevelopment of other malignancies
06
Interacting drugs
Monoclonal antibodies targeting EGFR/HER2
1 more in the full profile.
07
Biomarkers
EGFR mutations (e.g., in lung cancer)HER2 overexpression (e.g., in breast cancer)
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