Target intelligence / Profile preview

Epidermal Growth Factor Receptor (Mutated) (EGFR (mutated))

Target: EGFR (mutated)
Molecular classification: Receptor tyrosine kinase, Transmembrane receptor

Overview

The epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB family of receptor tyrosine kinases. Mutations or overexpression of EGFR are common drivers in various cancers, particularly non-small-cell lung cancer (NSCLC). Key mutations include exon 19 deletions, exon 21 L858R point mutation, T790M resistance mutation in exon 20, and S768I/L861Q/G719X mutations. Targeting mutated forms of EGFR has become standard care for certain cancers with therapies like osimertinib, afatinib, and amivantamab-vmjw.

Other names: ErbB1 (mutated)HER1 (mutated)

Mechanism of action

Tyrosine kinase inhibition

Biological functions

Cell proliferationCell survivalCell migrationCell differentiationSignal transduction

Disease associations

CancerNon-small-cell lung cancer (NSCLC)Metastatic colorectal cancerGlioblastomaHead and neck cancersPancreatic cancerBreast cancer

Safety considerations

Resistance to targeted therapiesAdverse drug reactionsDisease progression

Interacting drugs

Osimertinib

5 more in the full profile.

Biomarkers

Exon 19 deletionsExon 21 L858R point mutationT790M resistance mutation in exon 20S768I mutationL861Q mutationG719X mutationsExon 20 insertions

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