Epidermal Growth Factor Receptor Exon 19 Deletion Mutant

The epidermal growth factor receptor (EGFR) exon 19 deletion mutant refers to a group of activating mutations within exon 19 of the EGFR gene. These mutations are most commonly found in non-small cell lung cancer (NSCLC), particularly adenocarcinoma, and are associated with increased sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Exon 19 deletions result in constitutive activation of the intracellular tyrosine kinase domain, leading to ligand-independent dimerization and activation of downstream signaling pathways that drive oncogenic cell proliferation and survival.

Other names

EGFR Exon 19 DeletionEGFR del19

Tyrosine Kinase Inhibitor (TKI)