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Target intelligence / Profile preview
Epidermal Growth Factor Receptor kinase (EGFR)
- Target
- EGFR
- Molecular classification
- Receptor tyrosine kinase, ErbB/HER receptor tyrosine kinases
01
Overview
EGFR is a transmembrane receptor tyrosine kinase that belongs to the ErbB family of receptors. It plays a central role in regulating cell growth, survival, proliferation, and differentiation. Dysregulation of EGFR, through overexpression or activating mutations, is implicated in various cancers, making it an important therapeutic target. Therapeutic strategies targeting EGFR include monoclonal antibodies and small molecule inhibitors.
- Other names
- ErbB1HER1
02
Mechanism of action
Tyrosine kinase inhibition, receptor blockade
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalSignal transductionTissue homeostasisWound healingInnate immune response
04
Disease associations
Cancer
05
Safety considerations
Skin rashDiarrheaInterstitial lung diseaseResistance to targeted therapiesCardiotoxicity
06
Interacting drugs
5 more in the full profile.
07
Biomarkers
EGFR mutations (e.g., Exon 19 deletions, L858R, T790M, Exon 20 insertions)EGFR protein expressionEGFR gene amplification
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