Target intelligence / Profile preview

Epidermal Lipid Matrix (ELM)

Target: ELM
Molecular classification: Lipid mixture, Extracellular matrix component

Overview

The epidermal lipid matrix is a highly organized, hydrophobic structure located in the stratum corneum (SC), filling the spaces between corneocytes. It is composed primarily of ceramides, cholesterol, and free fatty acids, arranged in lamellar layers. This matrix functions as a critical barrier, preventing excessive water loss and blocking the entry of external substances. Disruptions in lipid composition and organization are associated with impaired barrier function and various skin disorders.

Other names: Stratum Corneum Lipid MatrixSC Lipid MatrixIntercellular Lipid MatrixEpidermal Barrier Lipids

Mechanism of action

Topical application aims to replenish deficient lipids, restore lamellar structure, and improve barrier function. Some formulations stimulate endogenous lipid synthesis.

Biological functions

Barrier functionWater retentionPrevention of transepidermal water loss (TEWL)Protection against environmental agentsSkin hydrationRegulation of permeability

Disease associations

Atopic dermatitisXerosisIchthyosisPsoriasisOther skin disorders with impaired barrier function

Safety considerations

Irritation from topical applicationsAllergic reactions to specific lipid componentsPotential for comedogenicity with certain lipid formulationsExacerbation of underlying skin conditions with inappropriate product use

Interacting drugs

Topical emollients

4 more in the full profile.

Biomarkers

Transepidermal water loss (TEWL)Skin hydration levelsCeramide levels in stratum corneumFatty acid composition in stratum corneumCholesterol levels in stratum corneumpH of the stratum corneum

Beyond the preview

Go deeper on Epidermal Lipid Matrix (ELM).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Epidermal Lipid Matrix (ELM).

Explore the full profile