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Epididymal secretory protein E3-alpha (EDDM3A)
- Target
- EDDM3A
- Molecular classification
- Other (Secreted protein of unclear enzyme/receptor/classification; not classified as receptor, enzyme, transporter, channel, GPCR, or transcription factor)
01
Overview
Epididymal secretory protein E3-alpha (EDDM3A) is a protein encoded by the EDDM3A gene, and is predominantly secreted by epithelial cells lining the epididymal duct in the male reproductive tract[1][5][10]. It is thought to play a role in sperm maturation by contributing new glycoproteins to the sperm membrane as part of the post-testicular modification process necessary for sperm motility and fertility[1][3][10]. This protein is not classified as a receptor, enzyme, or transporter, and does not currently have documented pharmacological interactors or recognized disease targeting roles. Main aliases include FAM12A, HE3A, HE3-ALPHA, and several sperm-related synonyms[1][3][5][10].
- Other names
- Epididymal protein 3AFAM12AHE3AHE3-ALPHAHuman epididymis-specific protein 3-alphaEP3ARAM1epididymis secretory sperm binding proteinfamily with sequence similarity 12 member Aribonuclease A M1
02
Biological functions
Sperm maturationAddition/modification of sperm membrane components via secreted protein action in epididymis
03
Disease associations
Other (No direct implication in major disease categories; weak association to "Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Thin Corpus Callosum" reported)
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