Epididymal-specific lipocalin-6 (LCN6)

Epididymal-specific lipocalin-6 (LCN6) is a member of the lipocalin protein family, characterized by a conserved eight-stranded antiparallel β-barrel structure capable of binding and transporting hydrophobic molecules[1][4][6][5]. LCN6 is highly specific to the human epididymis at the transcript level and is localized on spermatozoa, suggesting a specialized function in human reproduction, potentially related to sperm maturation or interaction[1][5]. The protein is distinct in its sequence but retains the classic lipocalin fold, indicating evolutionary conservation within this gene family[1]. Unlike other closely related lipocalins, LCN6 lacks a c-terminal cysteine, possibly allowing for a broader ligand range[1]. Functional and disease associations are currently limited; there is no direct evidence for roles in major diseases or as a therapeutic target[1][5].

Other names

Lipocalin-6LCN6Lipocalin-5LCN5UNQ643/PRO1273hLcn5epididymal-specific lipocalin-6epididymal-specific lipocalin LCN6epididymis secretory sperm binding proteinlipocalin 5UNQ643