Epigenetic programs in ocular tissues

Epigenetic programs in ocular tissues comprise the dynamic and heritable modifications of chromatin and DNA—such as DNA methylation, histone modifications, and regulation by non-coding RNAs—that control gene expression during eye development, tissue specification, and maintenance. These mechanisms are essential for normal function and homeostasis of the retina, retinal pigment epithelium, the lens, and other ocular structures, and their dysregulation has been implicated in a wide range of eye diseases, including cataract, glaucoma, diabetic retinopathy, age-related macular degeneration, and ocular tumors. Epigenetic patterns in eye cells can be influenced by environmental exposures, aging, oxidative stress, and disease states. While not a singular druggable entity, the collective processes of epigenetic regulation are considered promising therapeutic entry points, with ongoing research focused on targeting specific regulatory enzymes and pathways in ocular disease contexts.

Other names

Epigenetic regulation in eyeEpigenetic mechanisms in ocular tissuesEpigenetic control in ocular tissuesOcular epigenetic regulation