Target intelligence / Profile preview

Epiregulin

Molecular classification: Epidermal Growth Factor (EGF) family, Growth factor

Overview

Epiregulin is a multifunctional member of the EGF family that signals through EGFR/ErbBs to regulate diverse processes from embryonic development through wound healing—and when dysregulated—contributes significantly to oncogenesis across many tissues.

Mechanism of action

Inhibition of epiregulin action to reduce overactivity; supplementation to enhance tissue regeneration

Biological functions

Cell proliferationAngiogenesisVascular remodelingInflammation responseTissue repairWound healingOocyte maturationNeocortex development

Disease associations

CancerInflammation

Safety considerations

Potential for promoting cancer progression if over-supplementedComplex role in different cancers - may inhibit growth in some contexts, promote in others

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