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Target intelligence / Profile preview
Epithelial Cell Chloride Channel (ClC)
- Target
- ClC
- Molecular classification
- Ion channel, Transmembrane protein, Ligand-gated ion channel, Voltage-gated ion channel, ATP-binding cassette transporter
01
Overview
Epithelial cell chloride channels are integral membrane proteins facilitating chloride ion transport across epithelial cell membranes. They regulate transepithelial salt and water movement, cell volume, membrane potential, and signal transduction. Major types include CFTR, voltage-gated ClCs, and calcium-activated ClCs. Dysfunction results in diseases like cystic fibrosis and myotonia.
- Other names
- Chloride channelCl- channelCFTRClC-2CaCCGABA_A receptor
02
Mechanism of action
Modulation of chloride ion transport across cell membranes via various mechanisms including cAMP-dependent phosphorylation, voltage-gating, calcium activation, and ligand binding.
03
Biological functions
Ion transportRegulation of cell volumeTransepithelial transportMembrane potential stabilizationSignal transductionFluid secretionElectrolyte balance
04
Disease associations
Cystic fibrosisMyotonia congenitaSecretory diarrheaPulmonary diseasePancreatic insufficiency
05
Safety considerations
Off-target effects of channel modulatorsElectrolyte imbalanceDrug-drug interactions
06
Interacting drugs
CFTR potentiators
3 more in the full profile.
07
Biomarkers
CFTR mutation analysisSweat chloride testAirway surface liquid composition
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