Target intelligence / Profile preview

Epithelial cell transforming sequence 2 oncogene-like (ECT2L)

Target: ECT2L
Molecular classification: Other (putative guanine nucleotide exchange factor, F-box domain containing protein)

Overview

Epithelial cell transforming sequence 2 oncogene-like (ECT2L) is a human protein encoded by the ECT2L gene on chromosome 6. It is predicted to act as a guanine nucleotide exchange factor (GEF), and contains F-box and DH (Dbl homology) domains. Clinically, recurrent mutations in this gene have been associated with cases of acute lymphoblastic leukemia and other hematologic cancers. Its precise molecular function and broader biological roles remain under-characterized, and it is not currently a validated therapeutic target[3][4][5][10].

Other names: ARHGEF32C6orf91FBXO49LFDHLung-specific F-box and DH domain-containing proteinPutative guanine nucleotide exchange factor LFDHF-box protein 49dJ509I19.2dJ509I19.3dJ509I19.5

Biological functions

Guanine nucleotide exchange factor activity

Disease associations

Cancer (acute lymphoblastic leukaemia)Hematologic cancerCombined oxidative phosphorylation deficiency 9

Beyond the preview

Go deeper on Epithelial cell transforming sequence 2 oncogene-like (ECT2L).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Epithelial cell transforming sequence 2 oncogene-like (ECT2L).

Explore the full profile