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Epithelial Glycoprotein Mucin (Mucin)
- Target
- Mucin
- Molecular classification
- Glycoprotein, Membrane-associated mucin, Secreted mucin
01
Overview
Epithelial glycoprotein mucins are a family of high molecular weight, heavily glycosylated proteins found on the apical surface of epithelial cells. They provide barrier protection, lubrication, and immune modulation. Aberrant expression and glycosylation are frequently observed in cancer, making them potential therapeutic targets and diagnostic markers.
- Other names
- MUC1MUC2MUC3MUC4MUC5ACMUC5BMUC6MUC7MUC8Epithelial Membrane AntigenEMAPolymorphic Epithelial MucinPEMCA15-3
02
Mechanism of action
Variable depending on mucin type; can involve blocking adhesion, modulating immune response, or disrupting barrier function
03
Biological functions
Barrier protectionLubricationImmune modulationSelective uptake
04
Disease associations
CancerInflammationInfection
05
Safety considerations
Potential for off-target effects due to widespread expressionChallenges in targeting specific mucin isoforms
06
Biomarkers
CA15-3 (for MUC1 in breast cancer)Specific mucin glycoforms as diagnostic or prognostic markers
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