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Target intelligence / Profile preview
Epithelial-Mesenchymal Transition (EMT)
- Target
- EMT
- Molecular classification
- Cellular process, Developmental process, Signaling pathway
01
Overview
Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells lose their characteristic polarity and cell-cell adhesion, acquiring migratory and invasive properties typical of mesenchymal cells. EMT plays essential roles in embryonic development, tissue repair, and cancer progression. The reverse process—mesenchymal-to-epithelial transition (MET)—is also critical for normal development, stem cell reprogramming, cancer metastasis colonization at distant sites, and wound healing resolution. Dysregulated induction or failure to resolve EMT contributes to pathological conditions like fibrosis and cancer metastasis. Key inducers include TGF-beta and TNF-alpha, which activate transcriptional regulators like Snail, Slug, and Twist. Targeting EMT pathways represents a therapeutic opportunity for metastatic cancers and fibrotic diseases.
- Other names
- EMT/METEpithelial to Mesenchymal TransitionMesenchymal-Epithelial Transition
02
Mechanism of action
Inhibition of EMT signaling pathways (e.g., TGF-beta, Wnt); Induction of MET signaling pathways.
03
Biological functions
Cell migrationCell adhesionExtracellular matrix remodelingEmbryonic developmentTissue repairWound healingCell differentiation
04
Disease associations
Cancer metastasisFibrosisDevelopmental disorders
05
Safety considerations
Off-target effects on normal EMT processesPotential for promoting MET and tumor colonization if not carefully targetedDevelopment of resistance to EMT-targeted therapies
06
Biomarkers
E-cadherin expressionN-cadherin expressionVimentin expressionSnail expressionSlug expressionTwist expression
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