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Target intelligence / Profile preview
Epithelial Mucin 1 (MUC1)
- Target
- MUC1
- Molecular classification
- Transmembrane glycoprotein, Mucin
01
Overview
Epithelial Mucin 1 (MUC1) is a transmembrane glycoprotein expressed on the apical surface of most glandular and ductal epithelial cells. It plays a protective role by forming a physical barrier against pathogens and environmental stressors. MUC1 is often overexpressed or aberrantly glycosylated in various cancers, where it promotes tumor growth, invasion, metastasis, and immune evasion. The cytoplasmic tail of MUC1 mediates cell signaling, regulating proliferation, adhesion, motility, and survival.
- Other names
- EMAEpithelial Membrane AntigenPEMPolymorphic Epithelial MucinMCDPUMKL-6MAM6CD227
02
Mechanism of action
Inhibition of MUC1-mediated signaling pathways; targeting MUC1 for immunotherapy or drug delivery.
03
Biological functions
Barrier protectionLubricationCell signalingAntimicrobial defenseCell adhesionCell motilityCell survivalKidney development
04
Disease associations
CancerChronic inflammatory diseases
05
Safety considerations
Potential for off-target effects due to widespread epithelial expressionImmunogenicity of MUC1-targeted therapiesTumor immune evasion
06
Biomarkers
MUC1 overexpression in tumorsAberrant MUC1 glycosylation
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