Epithelial sodium channel subunit gamma (SCNN1G)

Epithelial sodium channel subunit gamma (SCNN1G) is a pore-forming subunit of the epithelial sodium channel (ENaC), an amiloride-sensitive, non-voltage-gated ion channel crucial for sodium reabsorption across epithelial tissues. The ENaC complex, assembled as a heterotrimer of alpha, beta, and gamma subunits, is essential for regulating sodium and water balance in the kidney, lung, and other epithelia, affecting blood volume and blood pressure. Mutations in SCNN1G cause rare monogenic hypertension (Liddle syndrome) and hypotension (pseudohypoaldosteronism type I) syndromes and contribute to common blood pressure variation and cardiovascular risk. ENaC function is targeted by drugs (notably amiloride) used to treat hypertension and fluid overload. The channel is regulated by hormones such as aldosterone and is expressed in tissues including kidney tubules, airway epithelia, distal colon, and taste buds, where it also plays a role in salt perception.

Other names

Sodium channel epithelial 1 subunit gammaAmiloride-sensitive sodium channel subunit gammaENaC subunit gammaENaCgammaGamma-ENaCNonvoltage-gated sodium channel 1 subunit gammaSCNEGBESC3LDLS2PHA1PHA1B3ENaCgENaCGGamma-NaCH

Blockade of sodium conductance via ENaC by direct binding (blocker/antagonist) – e.g., by amiloride