Epithelial splicing regulatory protein 1 (ESRP1)

Epithelial splicing regulatory protein 1 (ESRP1) is a cell-type specific RNA-binding protein characterized by three conserved RNA recognition motifs. It is expressed specifically in epithelial cells and orchestrates regulated alternative splicing events crucial for the maintenance of epithelial cell properties, including barrier function and cell-cell adhesion. ESRP1 and its closely related paralog ESRP2 manage the decision between epithelial and mesenchymal splicing programs, particularly during the EMT process, which is fundamental to development, wound healing, and cancer metastasis. Aberrant ESRP1 expression and activity are linked to the progression, invasion, and metastasis of multiple solid tumors. ESRP1's regulatory functions involve key cellular processes including proliferation, apoptosis, and migration, with specific influence on genes like CD44, FGFR2, ENAH, and CARM1. While not currently a direct pharmacological target, it is emerging as a putative biomarker and therapeutic target for cancer diagnosis, prognosis, and intervention.

Other names

ESRP1RBM35AFLJ20171RNA-binding motif protein 35ARNA-binding protein 35ADFNB109

Drugs modulating ESRP1 expression or activity could affect cancer cell sensitivity to chemotherapy (by altering alternative splicing of key resistance mediators such as CARM1)