Target intelligence / Profile preview

Epoprostenol Receptor (IP)

Target: IP
Molecular classification: G protein-coupled receptor (GPCR)

Overview

The epoprostenol receptor, also known as the prostacyclin receptor or IP receptor, is a G protein-coupled receptor (GPCR) that mediates the effects of prostacyclin (PGI₂), also called epoprostenol. This receptor plays a critical role in vascular homeostasis by promoting vasodilation and inhibiting platelet aggregation.

Other names: Prostacyclin ReceptorProstaglandin I₂ receptor

Mechanism of action

Agonism of the IP receptor, leading to increased cAMP production and downstream signaling events, resulting in vasodilation and inhibition of platelet aggregation.

Biological functions

VasodilationPlatelet inhibitionRegulation of vascular toneAnti-inflammationAnti-proliferation

Disease associations

Pulmonary arterial hypertensionCardiovascular diseaseInflammation

Safety considerations

Hypotension

Interacting drugs

Epoprostenol

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