Target intelligence / Profile preview

Epoxide Hydrolase

Molecular classification: Enzyme, Hydrolase, α/β-hydrolase fold enzymes

Overview

Epoxide hydrolases (EHs) are enzymes that catalyze the hydrolysis of epoxides into diols. They play a critical role in detoxification, metabolism of endogenous lipid mediators, and regulation of various signaling pathways. Several isoforms exist, including microsomal EH (mEH/EPHX1), soluble EH (sEH/EPHX2), and EPHX3/EHPX4, each with distinct tissue distribution and substrate preferences. sEH, in particular, is a therapeutic target for cardiovascular and inflammatory diseases due to its role in regulating bioactive lipids like EETs. The catalytic mechanism involves a two-step process with nucleophilic attack and water-mediated ester hydrolysis. Dysregulation of EHs is associated with various diseases, making them attractive therapeutic targets.

Other names: Epoxide HydrataseEHmEHsEHEPHX1EPHX2EPHX3EPHX4

Mechanism of action

Inhibition of epoxide hydrolysis

Biological functions

DetoxificationMetabolism of xenobioticsRegulation of lipid mediatorsHydrolysis of epoxidesModulation of vascular toneRegulation of inflammationRegulation of nociceptionRegulation of angiogenesisRegulation of cell homeostasis

Disease associations

HypertensionDiabetes mellitus type IICardiac hypertrophyPain syndromesNeurodegenerative diseaseAlzheimer's diseaseCancerCardiovascular disease

Safety considerations

Potential for off-target effects due to broad substrate specificitySpecies-specific differences in enzyme activity and substrate preference

Beyond the preview

Go deeper on Epoxide Hydrolase.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Epoxide Hydrolase.

Explore the full profile