EPS8 signaling adaptor L1 (EPS8L1)

EPS8 signaling adaptor L1 (EPS8L1) is a cytoskeletal-associated signaling adapter protein related to EPS8, which is a substrate for the epidermal growth factor receptor (EGFR)[3][6]. EPS8L1 is part of a family of proteins that mediate signal transduction from receptor tyrosine kinases (RTKs) to the actin cytoskeleton, primarily through interaction with other proteins such as Abi1 and Sos-1, and is involved in actin remodeling and membrane ruffling in response to growth factor stimulation[1]. Like EPS8, EPS8L1 contains an SH3 (Src homology 3) domain and a conserved C-terminal region important for binding with F-actin, suggesting a role in cytoskeleton organization and dynamic cell structures[1][3]. However, the detailed function and physiological role of EPS8L1 remain incompletely determined. It is not currently recognized as a therapeutic target, and there are no known drugs or direct mechanistic interventions for this protein[3][6]. EPS8L1 is associated with genetic disorders such as fetal akinesia deformation sequence and may play a role in cancer biology, but it is not itself a clinical biomarker or target for drug therapy at this time[3][4]. Functional redundancy within the EPS8 protein family suggests that loss of EPS8L1 can be compensated by related proteins[1][3].

Other names

EPS8L1EPS8-like 1 proteinEpidermal growth factor receptor pathway substrate 8-like protein 1Q8TE68 (UniProt ID)

Not applicable; no drugs target EPS8L1 directly