Target intelligence / Profile preview

Epstein-Barr Nuclear Antigen 1

Molecular classification: Transcription factor, Viral protein

Overview

Epstein-Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric DNA-binding protein encoded by the Epstein-Barr virus (EBV). It is essential for the replication and maintenance of the viral episome during latent infection and is consistently expressed in all EBV-associated tumors. EBNA1 is unique as it is the only EBV protein found in every form of EBV latency, making it a critical marker and therapeutic target for EBV-related malignancies.

Other names: EBNA-1Epstein–Barr virus nuclear antigen 1EBV nuclear antigen 1

Mechanism of action

Disrupting DNA binding or dimerization

Biological functions

Episome maintenanceViral replicationChromosome tetheringTranscriptional regulationImmune evasion

Disease associations

CancerInfection

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