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Target intelligence / Profile preview
Epstein-Barr Virus-Infected B Cells (EBV-Infected B Cells)
- Target
- EBV-Infected B Cells
- Molecular classification
- Cell, B Lymphocyte, Virus-Infected Cell
01
Overview
Epstein-Barr virus (EBV)-infected B cells are human B lymphocytes that have been targeted and infected by the Epstein-Barr virus. The primary cellular targets for EBV in humans are B cells due to their expression of specific surface receptors required for viral entry, primarily CD21. EBV establishes different latency programs within infected B cells, allowing for lifelong persistence while minimizing immune detection. While most infections are asymptomatic due to effective immune control, persistent infection can contribute to various malignancies.
- Other names
- EBV-Transformed B CellsEBV Positive B LymphocytesEBV+ B Cells
02
Biological functions
Viral replicationImmune evasionCell proliferationLatencyB cell activation
03
Disease associations
Infectious mononucleosisBurkitt lymphomaHodgkin lymphomaPost-transplant lymphoproliferative disorder (PTLD)Nasopharyngeal carcinomaEBV-associated malignancies
04
Safety considerations
Potential for oncogenesisImmune evasion leading to persistent infectionRisk of lymphoproliferative disorders in immunocompromised individuals
05
Biomarkers
EBV viral loadEBNA expressionLMP1 expressionCD21 expression
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