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Target intelligence / Profile preview
Epstein-Barr Virus-infected cell
- Molecular classification
- Host cell, Virus-infected cell
01
Overview
Epstein-Barr virus (EBV)-infected cells are host cells—primarily B lymphocytes, but also T cells, NK cells, and epithelial cells—that harbor the EBV genome. EBV establishes either a lytic or latent infection in these host cells. In latency, EBV persists as an episome within the nucleus and expresses specific viral proteins and RNAs that modulate cell behavior and immune evasion. EBV-infected cells can give rise to various malignancies and other diseases.
02
Mechanism of action
N/A
03
Biological functions
Viral replicationImmune evasionCell proliferationCell survival
04
Disease associations
Infectious mononucleosisBurkitt lymphomaHodgkin lymphomaNasopharyngeal carcinomaCancerInfection
05
Safety considerations
Risk of oncogenesisPotential for viral reactivationImmune suppression
06
Biomarkers
Anti-EBV antibodiesEBV viral load (PCR)EBV-encoded RNA (EBER) expressionEBNA1 expressionLMP1 expression
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