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Target intelligence / Profile preview
Epstein-Barr Virus-Infected Tumor Cell (EBV-Infected Tumor Cell)
- Target
- EBV-Infected Tumor Cell
- Molecular classification
- Cell, Infected Cell, Tumor Cell
01
Overview
Epstein-Barr virus (EBV)-infected tumor cells are malignant or transformed cells that harbor latent or lytic EBV infection. These cells are associated with various cancers, including lymphomas, nasopharyngeal carcinoma, and gastric carcinoma. EBV infection drives oncogenesis by modifying host gene expression, inducing EMT and angiogenesis, and facilitating immune escape. The molecular profile of these cells depends on the type of latency program expressed (Latency I, II, or III), which dictates which viral genes are expressed. Detection methods include in situ hybridization for EBERs and immunohistochemistry for viral proteins. Targeting these cells therapeutically presents challenges due to the complex interplay between viral and host factors, as well as potential safety concerns related to immune modulation.
- Other names
- EBV+ Tumor CellEBV-associated TumorEpstein-Barr Virus Positive Tumor Cell
02
Biological functions
Cell proliferationImmune evasionAngiogenesisEpithelial-mesenchymal transition (EMT)Survival
03
Disease associations
CancerLymphomaNasopharyngeal CarcinomaGastric CarcinomaSmooth Muscle TumorsImmunodeficiency-associated Malignancies
04
Safety considerations
Potential for off-target effects when targeting EBV-related pathwaysRisk of immune-related adverse events when manipulating the tumor microenvironment
05
Biomarkers
EBER expressionEBNA1 expressionLMP2A expression
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