Nucleoside Transporter (NT)

Nucleoside transporters are membrane proteins responsible for the transport of nucleosides and nucleobases across cell membranes. They are crucial for nucleotide salvage, cellular metabolism, and the pharmacokinetics of many drugs. Two main classes exist: equilibrative (ENTs) that facilitate passive transport, and concentrative (CNTs) that mediate active, sodium/proton-coupled uptake. They play a key role in the uptake of therapeutic agents including cytotoxic anticancer drugs and antiviral medications, and their altered expression can impact drug efficacy/resistance.

Other names

Equilibrative Nucleoside TransporterENTConcentrative Nucleoside TransporterCNTSLC29 familySLC28 family

Facilitated diffusion or active transport of nucleosides and nucleobases; influences intracellular drug concentration and efficacy.