Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ER membrane protein complex subunit 1 (EMC1)
- Target
- EMC1
- Molecular classification
- ER membrane protein complex, single-pass transmembrane protein, WD repeat family
01
Overview
ER membrane protein complex subunit 1 (EMC1) is a single-pass type I transmembrane protein and a founding subunit of the ER membrane protein complex (EMC), an assembly that mediates insertion and folding of multi-pass and tail-anchored membrane proteins, especially those with challenging transmembrane domains. Human EMC1 contains a β-propeller domain, is structurally related to proteins that mediate substrate interactions, and plays wider roles in protein quality control, IP maturation, ER-mitochondrial tethering, and cholesterol regulation. Germline mutations in EMC1 cause multisystem developmental disorders with neurological and visual impairment. EMC1 is not the direct focus of current clinical drug development, but its complex is essential to integral membrane protein biosynthesis in eukaryotes
- Other names
- EMC1KIAA0090
02
Mechanism of action
Not applicable, as no drugs are reported to target EMC1 directly.
03
Biological functions
Membrane protein biogenesis and insertionProtein folding and assembly in the ERER-mitochondrial tetheringMaintenance of cholesterol homeostasis
04
Disease associations
Retinal dystrophyDevelopmental disorders with cerebellar atrophy, hypotonia, visual impairment, psychomotor retardationCancer (correlation of EMC subunit dysregulation with malignancies)Susceptibility to viral infection
05
Safety considerations
No direct safety concerns documented for EMC1 as a drug target; EMC subunit dysfunction could affect ER protein homeostasis and cause broad cellular dysfunction, making therapeutic targeting challenging
06
Biomarkers
Mutations in EMC1 are associated with certain developmental and retinal diseases, but EMC1 itself is not an established biomarker for patient selection or efficacy monitoring yet
Beyond the preview
Go deeper on ER membrane protein complex subunit 1 (EMC1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ER membrane protein complex subunit 1 (EMC1).