ER membrane protein complex subunit 2 (EMC2)

ER membrane protein complex subunit 2 (EMC2) is a conserved, cytosolic subunit of the ER membrane protein complex (EMC), which is essential for the insertion of specific transmembrane helices from newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. EMC2 helps form the cytosolic disc region of the EMC through a series of tetratricopeptide repeats (TPRs) that serve as a scaffold for protein-protein interactions between other core EMC subunits. By aiding both cotranslational insertion of multi-pass membrane proteins and post-translational insertion of tail-anchored proteins, EMC2 is indirectly involved in the biogenesis of various membrane proteins including G protein-coupled receptors. As part of the broader EMC, EMC2 does not itself possess enzymatic or receptor activity, nor is it presently a direct drug target; rather, its proper function is necessary for the accurate assembly and maturation of many membrane proteins critical to cell and organelle physiology. No drugs currently target EMC2 specifically, and the gene is not commonly associated with direct disease mutations, though EMC dysfunction can have broad bioenergetic and signaling consequences.

Other names

EMC2KIAA0103TTC35Tetratricopeptide repeat protein 35TPR repeat protein 35