ER membrane protein complex subunit 6 (EMC6)

ER membrane protein complex subunit 6 (EMC6, also known as TMEM93) is a core component of the endoplasmic reticulum (ER) membrane protein complex (EMC), a multi-subunit machinery essential for the insertion and biogenesis of membrane proteins, particularly those with multiple or tail-anchored transmembrane domains. EMC6, together with EMC3, forms the core insertase module of the EMC and is highly conserved across species. In animals, EMC6 is necessary for correct trafficking, folding, and localization of crucial membrane proteins such as rhodopsin in photoreceptors, and its deletion leads to photoreceptor degeneration, abnormal cilia formation, and impaired protein transport. It is also implicated in cellular autophagy regulation and has been associated with apoptotic and inflammatory processes in specific tissues, but is not directly recognized as a therapeutic drug target at present.

Other names

Transmembrane protein 93 (TMEM93)MGC2963RAB5IFLTMEM93ER membrane protein complex subunit 6transmembrane protein 93