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Target intelligence / Profile preview
ERBB-3 receptor (HER3)
- Target
- HER3
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Type I transmembrane glycoprotein
01
Overview
ERBB-3 (HER3) is a receptor tyrosine kinase belonging to the ErbB family. While it has impaired kinase activity, it plays a crucial role in cell signaling, particularly through heterodimerization with other ErbB receptors like HER2, leading to activation of the PI3K/Akt pathway. HER3 is implicated in cancer development, progression, and resistance to therapies targeting other ErbB family members.
- Other names
- Receptor tyrosine-protein kinase erbB-3Human epidermal growth factor receptor 3
02
Mechanism of action
Inhibition of HER3 signaling, disruption of HER3 dimerization, targeting downstream effectors (e.g., PI3K/Akt)
03
Biological functions
Signal transductionCell proliferationCell survivalDimerizationPI3K/Akt pathway activationSrc kinase pathway activation
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential for off-target effects due to broad tissue distributionDevelopment of resistance mechanismsChallenges in targeting the pseudokinase domain
06
Biomarkers
HER3 expression levelsHER3 heterodimerization statusActivation status of downstream pathways (PI3K/Akt)
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