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Target intelligence / Profile preview
ErbB2 Receptor Tyrosine Kinase (HER2)
- Target
- HER2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
ErbB2 (HER2) is a receptor tyrosine kinase belonging to the ErbB family. It lacks a known direct ligand and primarily functions as a dimerization partner for other ErbB receptors, activating downstream signaling pathways that regulate cell proliferation, survival, and other cellular processes. Overexpression or amplification of HER2 is implicated in various cancers, particularly breast and gastric cancer, making it an important therapeutic target and biomarker.
- Other names
- ERBB2HER2/neuReceptor tyrosine-protein kinase erbB-2
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell survivalCell differentiationCell migrationSignal transductionInhibition of apoptosisRegulation of microtubule outgrowth/stabilizationTranscriptional regulationrRNA gene transcription
04
Disease associations
CancerFamilial visceral neuropathy type 2Glioma susceptibility
05
Safety considerations
Potential for off-target effectsDevelopment of resistance
06
Biomarkers
ERBB2 amplificationERBB2 overexpression
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