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Target intelligence / Profile preview
ERBB3 receptor (HER3)
- Target
- HER3
- Molecular classification
- Receptor, Receptor tyrosine kinase, ERBB family receptor
01
Overview
The ERBB3 receptor, also known as HER3, is a member of the EGFR/ERBB family of receptor tyrosine kinases. It binds ligands such as neuregulin-1 (NRG1) and signals primarily through heterodimers, most notably with ErbB2/HER2, activating downstream pathways like PI3K/Akt and MAPK. Although ERBB3 possesses weak intrinsic kinase activity, it plays a crucial role in promoting tumorigenesis and drug resistance in various cancers. Therapeutic strategies targeting ErbB receptors must consider ERBB3's unique biology and its ability to mediate resistance mechanisms.
- Other names
- human epidermal growth factor receptor 3Receptor tyrosine-protein kinase erbB-3
02
Mechanism of action
Inhibition of heterodimerization and downstream signaling pathways (PI3K/Akt, MAPK) using targeted therapies.
03
Biological functions
Signal transductionCell proliferationCell survivalCell growthDimerizationAutophosphorylation
04
Disease associations
CancerDrug resistanceLethal Congenital Contracture Syndrome
05
Safety considerations
Potential for compensatory signaling through other RTKsDevelopment of resistance mechanismsOn-target, off-tumor effects
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