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ERCC6L2 antisense RNA 1 (ERCC6L2-AS1)

Target
ERCC6L2-AS1
Molecular classification
Long non-coding RNA (lncRNA), Non-protein coding RNA
01

Overview

ERCC6L2 antisense RNA 1 (ERCC6L2-AS1) is a long non-coding RNA gene located on human chromosome 9, also known by aliases such as C9orf130 and LINC00476[3][7]. It does not encode a characterized protein and is classified as a non-coding RNA[5]. ERCC6L2-AS1 has been noted as "nasopharyngeal carcinoma-associated gene 12 protein" in some protein prediction databases[5], likely reflecting its identification in expression studies rather than confirmation as a functional protein. Current databases do not provide functional, mechanistic, or drug-interaction data for ERCC6L2-AS1. Its biological roles remain largely uncharacterized; no published experimental evidence details its precise mechanism, disease causality, or utility as a therapeutic target. Some studies indirectly connect it with nasopharyngeal carcinoma, but causal or functional roles have not been validated[5][7]. Thus, ERCC6L2-AS1 should be classified as a long non-coding RNA of unknown function, possibly involved in gene regulatory or epigenetic processes, with putative but unconfirmed relevance in specific cancers, particularly nasopharyngeal carcinoma.

Other names
C9orf130LINC00476NAG12Nasopharyngeal carcinoma-associated gene 12 proteinlong intergenic non-protein coding RNA 476NAG11ERCC6L2 antisense RNA 1
02

Mechanism of action

Not applicable; no drugs reported to target ERCC6L2-AS1

03

Biological functions

Likely involved in regulation of gene expressionPutative involvement in epigenetic or chromatin organizationUnknown/other (specific molecular functions not described in current literature)
04

Disease associations

Cancer (notably, nasopharyngeal carcinoma association as suggested by alias and locus studies)

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