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Target intelligence / Profile preview
ERCC8 antisense RNA 1 (ERCC8-AS1)
- Target
- ERCC8-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
ERCC8 antisense RNA 1 is a lncRNA gene located on the antisense strand of the ERCC8 protein-coding gene. Like other antisense RNAs, it likely regulates the expression of its sense counterpart and may impact DNA repair mechanisms. Recent studies have identified ERCC8-AS1 among several lncRNAs upregulated in cancers, such as osteosarcoma, and its altered expression may contribute to cancer progression or serve as a biomarker. The functional and clinical significance of ERCC8-AS1 in disease is under active investigation, but it is not currently a target of approved drugs
02
Mechanism of action
Not defined for drugs, as no drugs currently target ERCC8-AS1 specifically
03
Biological functions
Regulation of gene expression (at replication, transcription, and translation levels)Possible modulation of DNA repair via antisense regulation of ERCC8
04
Disease associations
Cancer (upregulation reported in osteosarcoma and some other tumors)Other (lncRNA dysregulation broadly associated with multiple diseases, but specific roles for ERCC8-AS1 are emerging)
05
Safety considerations
No clinical safety data or therapeutic challenge reports as ERCC8-AS1 is not yet a direct therapeutic target
06
Biomarkers
Upregulation in tumor samples (such as osteosarcoma) suggests potential use as a diagnostic or prognostic biomarker in cancer
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