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Target intelligence / Profile preview
Ergosterol
- Molecular classification
- Sterol, Lipid
01
Overview
Ergosterol is a sterol molecule found in the cell membranes of fungi and some protozoa, serving as a structural component analogous to cholesterol in animal cells. It regulates membrane fluidity and permeability and is a target for antifungal drugs. Ergosterol can also act as a microbe-associated molecular pattern, triggering immune responses. It is also a precursor to vitamin D2.
- Other names
- Provitamin D2(22E,24S)-24-methylcholesta-5,7,22-trien-3β-olMycota-Sterin
02
Mechanism of action
Azoles inhibit enzymes involved in ergosterol synthesis. Polyenes bind directly to ergosterol, disrupting membrane integrity.
03
Biological functions
Regulation of membrane permeabilityRegulation of membrane fluidityPrecursor of vitamin D2Antioxidant
04
Disease associations
Fungal infectionsImmune response
05
Safety considerations
Antifungal drug resistanceToxicity associated with antifungal drugs
06
Interacting drugs
Azoles (e.g., Fluconazole, Itraconazole)
1 more in the full profile.
07
Biomarkers
Ergosterol levels can be used as a biomarker for fungal presence and infection severity.
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