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Ergosterol Biosynthesis Enzyme

Molecular classification: Enzyme

Overview

Ergosterol biosynthesis enzymes are a group of proteins responsible for the multi-step conversion of simple precursors into ergosterol, the principal sterol in fungal cell membranes. Ergosterol serves functions analogous to cholesterol in animal cells, maintaining membrane fluidity, integrity, and regulating membrane-bound enzyme activities. Many antifungal drugs target these enzymes to disrupt membrane function in fungi.

Mechanism of action

Inhibition of ergosterol biosynthesis

Biological functions

Membrane structure/fluidityRegulation of transport and enzyme activitySterol biosynthesis

Disease associations

Infection

Safety considerations

Drug resistanceOff-target effects due to similarity with human cholesterol synthesis

Interacting drugs

Azoles

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