Erythrocyte membrane protein band 4.2 (EPB42)

Erythrocyte membrane protein band 4.2 (EPB42) is a peripheral membrane ATP-binding protein that is one of the most abundant components of the human red blood cell (erythrocyte) membrane[1][4][5]. It plays an essential role in stabilizing erythrocyte membrane structure, primarily by regulating the association between the band 3 protein and ankyrin, and is part of the ankyrin-1 complex[1][4][5]. Through its physical association with band 3, ankyrin, and CD47, protein 4.2 helps maintain the distinctive shape and mechanical properties of erythrocytes[4]. Deficiencies or mutations in EPB42 cause disorders such as hereditary spherocytosis and elliptocytosis, characterized by destabilization of the erythrocyte membrane and hemolytic anemia[1][4][5]. Protein 4.2 is structurally similar to members of the transglutaminase protein family, although it lacks transglutaminase enzymatic activity[2][4]. There is currently no evidence that it is a direct therapeutic target or that any drugs interact with it[1][4][5].

Other names

Protein 4.2EPB42E42PP4.2Erythrocyte protein 4.2PAMGC116735MGC116737Erythrocyte surface protein band 4.2SPH5