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Target intelligence / Profile preview
Erythroid differentiation regulatory factor 1 (EDRF1)
- Target
- EDRF1
- Molecular classification
- Other, Transcription factor (inferred, as it inhibits the DNA binding activity of GATA-1 and regulates globin gene expression)
01
Overview
Erythroid differentiation regulatory factor 1 (EDRF1) is a protein encoded by the EDRF1 gene located on human chromosome 10. This protein is implicated in the regulation of erythroid cell differentiation, primarily by inhibiting the DNA binding of the erythroid transcription factor GATA-1, which results in modulation of alpha-globin and gamma-globin gene expression. Alternative splicing of the EDRF1 transcript produces multiple protein variants. Although it is considered a putative transcription factor due to its regulatory effects on gene expression during erythropoiesis, there is currently no evidence that EDRF1 is a direct therapeutic target, nor are there known drugs or established biomarkers targeting this molecule[1][2][3][6][7].
- Other names
- Erythroid differentiation-related factor 1C10orf137DKFZp586F1019FLJ21617EDRF1
02
Biological functions
Erythroid cell differentiationRegulation of globin gene expressionInhibition of GATA-1 transcriptional activity
03
Disease associations
Other (No direct documented association with therapeutic disease targeting as of current knowledge)
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