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Erythropoietin (EPO)
- Target
- EPO
- Molecular classification
- Glycoprotein hormone, Cytokine, Growth factor
01
Overview
Erythropoietin (EPO) is a glycoprotein hormone primarily produced by the kidneys that stimulates the production of red blood cells in the bone marrow. It binds to the erythropoietin receptor (EpoR) on erythroid progenitor cells, activating the JAK2/STAT5 signaling pathway to promote their survival, proliferation, and differentiation. Recombinant forms of EPO are used therapeutically to treat anemia associated with chronic kidney disease, chemotherapy, and other conditions.
02
Mechanism of action
Binds to erythropoietin receptor (EpoR) on erythroid progenitor cells, activating the JAK2/STAT5 signaling pathway to promote survival, proliferation, and differentiation of erythroid precursors into mature red blood cells.
03
Biological functions
ErythropoiesisRed blood cell productionCell survivalCell proliferationCell differentiation
04
Disease associations
AnemiaChronic kidney diseaseChemotherapy-induced anemiaHIV therapy-related anemia
05
Safety considerations
HypertensionThromboembolic events
06
Interacting drugs
Epoetin alfa
1 more in the full profile.
07
Biomarkers
Reticulocyte countHemoglobin levelsHematocrit
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