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Target intelligence / Profile preview
Erythropoietin-producing hepatocellular carcinoma A2 receptor (EphA2)
- Target
- EphA2
- Molecular classification
- Receptor Tyrosine Kinase, Ephrin receptor subfamily
01
Overview
EphA2 is a receptor tyrosine kinase that binds to ephrin-A ligands, mediating bidirectional signaling involved in cell adhesion, migration, differentiation, and angiogenesis. It is overexpressed in many cancers and associated with poor prognosis. EphA2 also plays a role in lens transparency and serves as an entry receptor for KSHV. It is a therapeutic target for cancer, viral infections, and cataract disorders.
- Other names
- EPHA2EPH receptor A2ephrin type-A receptor 2epithelial cell kinase (Eck)
02
Mechanism of action
Agonist (Doxazosin); Tyrosine Kinase Inhibition; Antibody-mediated cell killing; Receptor blocking
03
Biological functions
Cell adhesionCell migrationDifferentiationAngiogenesisPattern formation during developmentBone remodelingLens fiber cell shape/interactionsEpithelial proliferationBranching morphogenesis
04
Disease associations
CancerCataractsViral entry (KSHV)
05
Safety considerations
Potential off-target effects of kinase inhibitorsCytokine release syndrome (CAR-T therapy)Immune-related adverse events
06
Interacting drugs
Doxazosin
3 more in the full profile.
07
Biomarkers
EphA2 overexpression in tumorsS897 phosphorylation
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