Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Erythropoietin-producing human hepatocellular receptor A2 (EphA2)
- Target
- EphA2
- Molecular classification
- Receptor Tyrosine Kinase, EPH receptor, EPHA receptor
01
Overview
Erythropoietin-producing hepatocellular receptor A2, commonly known as EphA2, is a receptor tyrosine kinase involved in cell signaling processes that regulate tissue organization, homeostasis, and cellular communication. It is often overexpressed in various cancers and implicated in inflammatory conditions. Therapeutic targeting has faced challenges related to toxicity and delivery.
- Other names
- EPHA2EPH receptor A2
02
Mechanism of action
Monoclonal antibodies and antibody-drug conjugates targeting EphA2
03
Biological functions
Cell-cell communicationBarrier integrity regulationTissue organizationCell adhesionInflammatory responseWound healing
04
Disease associations
Cancer progressionCancer metastasisLung injuryInflammationLiver fibrosisLiver carcinoma
05
Safety considerations
ThrombocytopeniaHypotensionPeripheral neuropathyBleeding eventsCoagulation defectsPoor tumor uptakeToxicity
06
Interacting drugs
DS-8895a
1 more in the full profile.
07
Biomarkers
EphA2 expression levels in tumors
Beyond the preview
Go deeper on Erythropoietin-producing human hepatocellular receptor A2 (EphA2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Erythropoietin-producing human hepatocellular receptor A2 (EphA2).