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Target intelligence / Profile preview
ESAT6-CFP10 fusion protein (ESAT6-CFP10)
- Target
- ESAT6-CFP10
- Molecular classification
- Recombinant protein, Antigen
01
Overview
The ESAT6-CFP10 fusion protein is a recombinant antigen composed of Early Secretory Antigenic Target 6 (ESAT-6) and Culture Filtrate Protein 10 (CFP-10) from Mycobacterium tuberculosis. It is used in skin tests and interferon-gamma release assays (IGRAs) to diagnose latent or active TB infection due to its high specificity and lack of cross-reactivity with BCG vaccination or most environmental mycobacteria. The fusion protein retains immunogenic properties that stimulate T-cell responses specific to M. tuberculosis infection and is considered a major virulence factor.
- Other names
- Early Secretory Antigenic Target 6-Culture Filtrate Protein 10 fusion proteinESAT-6-CFP-10 fusion proteinYiKa
02
Mechanism of action
Stimulates T-cell mediated immune response in individuals previously exposed to Mycobacterium tuberculosis, leading to IFN-gamma production or skin induration.
03
Biological functions
T-cell activationImmune response stimulationAutophagy inhibition (in macrophages)Diagnostic reagent
04
Disease associations
TuberculosisMycobacterium tuberculosis infection
05
Biomarkers
IFN-gamma levelsSkin induration
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