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Target intelligence / Profile preview
Escherichia coli Lipopolysaccharide (LPS)
- Target
- LPS
- Molecular classification
- Lipopolysaccharide, Cell membrane component, Glycolipid
01
Overview
Lipopolysaccharide (LPS), also known as endotoxin, is a major component of the outer membrane of Gram-negative bacteria such as Escherichia coli. It is essential for bacterial viability and plays a critical role in maintaining the structural integrity and barrier function of the bacterial outer membrane. LPS is an amphipathic molecule composed of three main domains: Lipid A, Core Oligosaccharide and O Antigen. It is a key target for antimicrobial agents and a potent activator of the host immune system, leading to inflammation and potentially sepsis.
- Other names
- EndotoxinE. coli LPS
02
Mechanism of action
Polymyxins bind to lipid A, disrupting the bacterial membrane. TLR4 antagonists block LPS-induced immune activation.
03
Biological functions
Structural integrity of bacterial outer membranePermeability barrierImmune system activationAntigen presentation
04
Disease associations
SepsisInflammationInfectionSeptic shock
05
Safety considerations
Induction of excessive inflammatory response (cytokine storm)Potential for antibiotic resistance development
06
Interacting drugs
Polymyxins
2 more in the full profile.
07
Biomarkers
LPS levels in blood (for sepsis diagnosis)TLR4 expression levels
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