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Escherichia coli O-polysaccharide antigen
- Molecular classification
- Polysaccharide, Lipopolysaccharide component
01
Overview
The Escherichia coli O-polysaccharide antigen, or O-antigen, is a highly variable component of the lipopolysaccharide (LPS) found on the outer membrane of Gram-negative bacteria such as E. coli. It consists of repeating oligosaccharide units, contributing to over 180 recognized serogroups. The O-antigen plays a critical role in bacterial virulence, aiding in immune evasion and resistance to complement-mediated killing and phagocytosis. It is also used in epidemiology for strain typing due to its high variability among strains.
- Other names
- E. coli O-antigenO-polysaccharideLPS O-antigenO-specific polysaccharide
02
Biological functions
Immune evasionVirulence factorBacterial surface structureAdhesion
03
Disease associations
InfectionBacterial pathogenesisSepsis
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