Escherichia coli O25B O-antigen epitope (O25B O-antigen)

The Escherichia coli O25B O-antigen epitope is a specific carbohydrate structure found within the lipopolysaccharide (LPS) layer of certain extraintestinal pathogenic E. coli (ExPEC) strains, most notably the multi-drug resistant ST131 clone. This O-antigen serves as a critical virulence factor by protecting the bacterium from host complement-mediated killing and facilitating colonization of host tissues. Due to its high prevalence in antibiotic-resistant infections, particularly urinary tract infections and neonatal sepsis, it has become a primary target for novel therapeutic interventions. Current drug development efforts focus on using this epitope as a vaccine candidate or as a target for monoclonal antibodies to provide passive immunity. By targeting the O25B epitope, these therapies aim to enhance opsonophagocytosis and neutralize the pathogen's ability to cause systemic infection.

Other names

Escherichia coli O25B O-antigenE. coli O25B O-antigenO25B antigenO25B lipopolysaccharide epitope