Target intelligence / Profile preview

Essential Fatty Acids (EFA)

Target
EFA
Molecular classification
Fatty Acids, Lipids
01

Overview

Essential fatty acids (EFAs) are polyunsaturated fatty acids that humans and other animals require for normal physiological function but cannot synthesize endogenously. They must be obtained through the diet. There are two primary families of EFAs: Omega-3 (n−3) and Omega-6 (n−6) fatty acids. EFAs serve as precursors to bioactive lipid mediators, are integral components of cell membranes, and play critical roles in various bodily functions including heart health, cognitive function, and skin health. A balanced ratio between dietary intake of n‐6:n‐3 is considered important.

Other names
Polyunsaturated Fatty AcidsPUFAsOmega-3 fatty acidsOmega-6 fatty acidsn-3 fatty acidsn-6 fatty acids
02

Biological functions

Cell membrane structurePrecursor for signaling moleculesGene regulationInflammation modulationBrain developmentVisionImmune modulationSkin integrityEicosanoid synthesisEndocannabinoid synthesisLipoxin synthesisResolvin synthesisNeuroprotectin synthesis
03

Disease associations

Cardiovascular diseaseInflammationNeurological disordersImmune disordersSkin disorders
04

Safety considerations

Potential for excessive Omega-6 intake promoting inflammationPotential for interactions with anticoagulant medications (high Omega-3 intake)

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