Establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1)

Establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) is an enzyme that catalyzes the acetylation of the cohesin complex component SMC3, a key step in enabling the stable pairing of sister chromatids after DNA replication[1][2][3]. ESCO1 is required for maintaining sister chromatid cohesion, genome stability, and chromatin organization, particularly outside of S phase (throughout the cell cycle)[2][3][6]. It operates by modifying SMC3, supporting cohesin's role in chromosome architecture, transcriptional regulation, and DNA repair[5][6]. While its paralog ESCO2 is essential for cohesion during S phase (DNA replication), ESCO1 supports non-replicative cohesion activities and helps organize higher-order chromatin structures in cooperation with factors such as CTCF and STAG1[2][6]. Mutations or loss of ESCO1 function are implicated in developmental syndromes and may contribute to cancer[1][4][5]. **Notes/References:** - ESCO1 has no known approved drugs directly targeting it clinically[1][3]. - No established biomarkers or safety/tolerability data for ESCO1-targeted therapies have been published as of 2024[1][5].

Other names

ESCO1EFO1KIAA1911EFO1phEFO1ECO1 homolog 1ESO1 homolog 1ESO1CTF7 homolog 1Establishment factor-like protein 1Establishment of cohesion 1 homolog 1A930014I12RikCTFECO1

Acetylation of cohesin subunit SMC3, Regulation of cohesin-chromatin interactions, Chromatin loop organization via SMC3 and CTCF acetylation