Estrogen-induced osteoclastogenesis regulator 1 (EEIG1)

Estrogen-induced osteoclastogenesis regulator 1 (EEIG1) is a cytoplasmic adaptor protein essential for osteoclast differentiation and bone resorption. It acts as a positive regulator of the RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenic pathway by physically interacting with RANK after RANKL stimulation. EEIG1 forms part of a membrane-associated signaling complex (with RANK, Gab2, Tec/Btk kinases, and PLCγ2) that facilitates downstream activation of PLCγ2 and the transcription factor NFATc1—both critical for osteoclast formation. Experimental inhibition of the EEIG1–RANK interaction blocks pathological bone resorption, suggesting therapeutic potential for conditions marked by excessive osteoclast activity. EEIG1 may also mediate some estrogen actions and is genetically associated with certain types of glaucoma[1][2][4][7].

Other names

Early estrogen-induced gene 1 proteinC9orf132FAM102ASYM-3Asym-3 homolog Afamily with sequence similarity 102 member Aprotein FAM102AbA203J24.7

Experimental inhibitory peptide blocking RANK–EEIG1 interaction reduces osteoclastogenesis