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Target intelligence / Profile preview
Estrogen receptor (ER)
- Target
- ER
- Molecular classification
- Receptor, Transcription factor, Nuclear hormone receptor
01
Overview
The estrogen receptor is a nuclear hormone receptor that mediates the biological effects of estrogens at the level of gene regulation. It exists in two main isoforms (ERα and ERβ) with distinct tissue distributions and functions. Upon binding estrogen, the receptor undergoes conformational changes, dimerizes, and binds to DNA to regulate gene expression. It plays crucial roles in reproductive physiology, bone health, cardiovascular function, and is implicated in various diseases, particularly hormone-dependent cancers.
- Other names
- Estrogen receptor alphaERαEstrogen receptor betaERβ
02
Mechanism of action
Ligand-dependent transcriptional activation, Ligand-independent transcriptional activation
03
Biological functions
Signal transductionGene regulationCell proliferation
04
Disease associations
CancerCardiovascular disease
05
Safety considerations
Differential tissue effects due to receptor subtype distribution
06
Interacting drugs
Estradiol
2 more in the full profile.
07
Biomarkers
ERα expression in breast cancer
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