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Estrogen Receptor Alpha mRNA (None)
- Target
- None
- Molecular classification
- mRNA, Transcription factor
01
Overview
Estrogen receptor alpha (ERα) mRNA is the messenger RNA transcript produced from the ESR1 gene, which encodes the estrogen receptor alpha protein. ERα is a nuclear hormone receptor and functions as a ligand-activated transcription factor that regulates the expression of estrogen-responsive genes. The ESR1 gene undergoes alternative splicing, resulting in several mRNA transcripts that primarily differ in their 5' untranslated regions. Alterations or dysregulation of ESR1/ERα are implicated in various diseases, most notably breast cancer. It's the target for endocrine therapies such as selective estrogen receptor modulators/degraders. Mutations or splice variants can affect responsiveness to therapy or contribute to resistance mechanisms.
- Other names
- ESR1 mRNAEstrogen Receptor 1 mRNA
02
Mechanism of action
Modulation of ESR1 mRNA expression via various mechanisms
03
Biological functions
Regulation of gene expressionCell proliferationCell differentiationReproductive functionBone healthCardiovascular system regulationMetabolism
04
Disease associations
Breast cancer
05
Safety considerations
Altered estrogen signaling can have broad physiological effectsResistance to endocrine therapies
06
Interacting drugs
Selective estrogen receptor modulators (SERMs)
1 more in the full profile.
07
Biomarkers
ESR1 mRNA expression levels in tumor tissue
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