Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Estrogen-related receptor beta (ERRβ)
- Target
- ERRβ
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
Estrogen-related receptor beta (ERRβ), encoded by the *ESRRB* gene, is an orphan nuclear receptor and transcription factor. It plays a critical role in regulating gene expression, particularly in the transition between naïve and primed pluripotent states. Unlike classical estrogen receptors, ERRβ does not bind estrogens but shares structural similarities. It regulates genes involved in metabolism, development, and cellular differentiation.
- Other names
- ESRRBNR3B2nuclear receptor subfamily 3, group B, member 2
02
Mechanism of action
Ligand-independent transcriptional activation via DNA binding; modulated by co-regulators and post-translational modifications.
03
Biological functions
Gene expression controlPluripotency regulationCellular differentiationMetabolic regulation
04
Disease associations
Hearing lossCancer (potential role)
Beyond the preview
Go deeper on Estrogen-related receptor beta (ERRβ).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Estrogen-related receptor beta (ERRβ).